Neurological Complications of Neurofibromatosis Type 1 and Modern Approaches to Their Surgical Correction
Keywords:
neurofibromatosis type I, neurological complications, spinal tumorsAbstract
Neurofibromatosis type I (NF1) is a genetically determined neurocutaneous disorder characterized by significant clinical variability and a high incidence of neurological complications. This study aimed to analyze the spectrum of neurological disorders associated with NF1 and to evaluate outcomes of surgical treatment for tumors affecting the peripheral and central nervous systems. A total of 112 patients aged 14–62 years underwent comprehensive evaluation. Spinal and spinal cord tumors were identified in 58% of cases, while clinically significant neural compression occurred in 16%. Surgical treatment was performed in 38 patients with symptomatic disease. Postoperative neurological improvement was achieved in 71% of cases. These findings highlight the importance of early diagnosis and timely surgical intervention in progressive NF1-related neurological complications
References
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
