Modern Arterial Hypertension: Nocturnal Hypertension, Inflammatory Mechanisms, And Personalized Therapy
Keywords:
arterial hypertension, nocturnal hypertension, inflammationAbstract
In recent years, arterial hypertension has been increasingly recognized not merely as a hemodynamic disorder, but as a complex, multifactorial disease closely associated with inflammatory processes and individual biological characteristics. This article examines the clinical significance of nocturnal and masked arterial hypertension, their role in the development of cardiovascular complications, and modern diagnostic approaches. Particular attention is paid to the role of 24-hour ambulatory blood pressure monitoring (ABPM) as the gold standard for detecting nocturnal hypertension, as well as to the prognostic value of non-dipper and reverse-dipper blood pressure patterns. In addition, the contribution of chronic low-grade inflammation to the pathogenesis of arterial hypertension is analyzed, with emphasis on key inflammatory biomarkers, including interleukin-6, tumor necrosis factor-alpha, and high-sensitivity C-reactive protein. The article also discusses current trends in personalized antihypertensive therapy, such as genetically guided drug selection, risk-oriented treatment strategies, and the use of artificial intelligence and digital technologies to optimize blood pressure control. It is emphasized that an individualized therapeutic approach improves blood pressure stability, reduces adverse effects, and significantly lowers the risk of cardiovascular complications.
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